Brain metastasis

Case contributed by Sanhita Shyam Pokle
Diagnosis almost certain

Presentation

The patient complains of a headache persisting for 1 month, accompanied by weakness. They underwent surgery for breast cancer and completed chemotherapy 1 year ago.

Patient Data

Age: 45 years
Gender: Female
mri

Well-defined rounded lesions with a hypointense rim and central necrosis on T2/FLAIR were observed. The lesions appeared hypointense on the T1-weighted image with rim restriction diffusion, and no blooming was observed on the GRE sequence. Perilesional edema was noted, with no midline shift detected.

mri

Multiple well defined enhancing lesions noted in the Bilateral parietal, left temporal and right medulla regions.

Lesions are T1 hypo-intense, T2/FLAIR heterogeneous with hypo-intense rim and central necrosis rim restriction diffusion on DWI/ADC, no blooming on FFE, with significant perilesional edema. No midline shift noted.

Case Discussion

This is a case of operated breast carcinoma with ER+ and HER2-negative status, having undergone 6 months of chemotherapy. Blood counts were normal. Given the typical location of lesions at the grey-white junction and brainstem, along with the peripheral and central enhancement, and considering the patient's past medical history, the most probable diagnosis is brain metastasis from breast cancer.

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