Multinodular and vacuolating posterior fossa lesion of unknown significance (MV-PLUS)
Presentation
Patient without neurological symptoms. Incidental finding during an MRI for research purposes.
Patient Data
Multicystic subcortical lesion of the superior vermis adjacent to the roof of the 4th ventricle. No associated contrast enhancement or diffusion restriction. Stable imaging findings over 2 years. Due to the lack of clinical symptoms, and the vulnerable location of the lesion, a biopsy was not performed.
Considering the clinical presentation, the imaging findings are primarily compatible with a multinodular and vacuolating posterior fossa lesion of unknown significance (MV-PLUS).
Case Discussion
MV-PLUS is thought to be a variant of multinodular and vacuolating neuronal tumor (MVNT), however, this has not yet been confirmed histologically. They appear to be benign indolent tumors that are usually asymptomatic.
Differential diagnosis includes dysembryoplastic neuroepithelial tumors (DNET). Continued follow-up imaging to ensure stability is therefore recommended.
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