The corpus callosum is a major axonal commissure of the brain connecting the two cerebral hemispheres and providing communication between the cortical and subcortical neurons.

Corpus callosum agenesis results from failure of the callosal commissural fibers to cross the midline and form the major connection between the two cerebral hemispheres.

It may be complete or partial and may occur in isolation or in association with other CNS or systemic malformations.