A thick corpus callosum without a focal lesion can be observed in some normal individuals. However, it may also indicate underlying abnormalities in the connecting tracts of the brain, as seen in neurodevelopmental disorders such as autism spectrum disorder or schizophrenia. This seems to be the case for this teenager, who exhibits various symptoms suggestive of abnormal brain function, including abnormal behavior, mental and language delays, and hyperactivity.

Acknowledgment: Nusaibah Ghaleb Yousef Alnahari